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dc.contributor.authorErramuzpe Aliaga, Asier
dc.contributor.otherNúñez-Ibero, Maider
dc.contributor.otherCamino-Pontes, B.
dc.contributor.otherDíez, Ibai
dc.contributor.otherMartínez-Gutiérrez, Endika
dc.contributor.otherStramaglia, Sebastiano
dc.contributor.otherAlvarez Cienfuegos Suárez, José María
dc.contributor.otherCortés Ormazabal, Jesús
dc.date.accessioned2022-06-10T09:00:05Z
dc.date.available2022-06-10T09:00:05Z
dc.date.issued2021
dc.identifier.issn2168-2194en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=164638en
dc.identifier.urihttp://hdl.handle.net/20.500.11984/5599
dc.description.abstractObjective: To develop a new device for identifying physiological markers of pain perception by reading the brain's electrical activity and hemodynamic interactions while applying thermoalgesic stimulation. Methods: We designed a compact prototype that generates well-controlled thermal stimuli using a computer-driven Peltier cell while simultaneously capturing electroencephalography (EEG) and photoplethysmography (PPG) signals. The study was performed on 35 healthy subjects (mean age 30.46 years, SD 4.93 years; 20 males, 15 females). We first determined the heat pain threshold (HPT) for each subject, defined as the maximum temperature that the subject can withstand when the Peltier cell gradually increased the temperature. Next, we defined the painful condition as the one occurring at temperature equal to 90% of the HPT, comparing this to the no-pain state (control) in the absence of thermoalgesic stimulation. Results: Both the one-dimensional and the two-dimensional spectral entropy (SE) obtained from both the EEG and PPG signals differentiated the condition of pain. In particular, the SE for PPG was significantly reduced in association with pain, while the SE for EEG increased slightly. Moreover, significant discrimination occurred within a specific range of frequencies, 26-30 Hz for EEG and about 5-10 Hz for PPG. Conclusion: Hemodynamics, brain dynamics and their interactions can discriminate thermal pain perception. Significance: The possibility of monitoring on-line variations in thermal pain perception using a similar device and algorithms may be of interest to study different pathologies that affect the peripheral nervous system, such as small fiber neuropathies, fibromyalgia or painful diabetic neuropathy.en
dc.language.isoengen
dc.publisherIEEEen
dc.rights© 2021 IEEEen
dc.subjectPainen
dc.subjectElectroencephalographyen
dc.subjectHeating systemsen
dc.subjectBiomedical monitoringen
dc.subjectPhysiologyen
dc.subjecttemperature measurementen
dc.subjectEntropyen
dc.titleA Controlled Thermoalgesic Stimulation Device for Exploring Novel Pain Perception Biomarkersen
dc.typeinfo:eu-repo/semantics/articleen
dcterms.accessRightsinfo:eu-repo/semantics/openAccessen
dcterms.sourceIEEE Journal of Biomedical and Health Informaticsen
dc.description.versioninfo:eu-repo/semantics/submittedVersionen
local.contributor.groupTeoría de la señal y comunicacioneses
local.description.peerreviewedfalseen
local.description.publicationfirstpage2948en
local.description.publicationlastpage2957en
local.identifier.doihttps://doi.org/10.1109/JBHI.2021.3080935en
local.contributor.otherinstitutionIkerbasquees
local.contributor.otherinstitutionEuskal Herriko Unibertsitatea (EHU)eu
local.contributor.otherinstitutionBioCruces Health Research Instituteen
local.contributor.otherinstitutionMassachusetts Institute of Technologyen
local.contributor.otherinstitutionHarvard Medical Schoolen
local.contributor.otherinstitutionUniversidad de Bari Aldo Moroes
local.contributor.otherinstitutionInstituto Nazionale di Fisica Nuclearees
local.source.detailsVol. 25. N. 8. P.p. 2948-2957, 2021en


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