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AControlledThermoalgesicStimulationDeviceForExploringNovelPainPerceptionBiomarkers.pdf (2.771Mb)
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Title
A Controlled Thermoalgesic Stimulation Device for Exploring Novel Pain Perception Biomarkers
Author
Erramuzpe Aliaga, Asier ccMondragon Unibertsitatea
Author (from another institution)
Núñez-Ibero, Maider
Camino-Pontes, B.
Díez, Ibai
Martínez-Gutiérrez, Endika
Stramaglia, Sebastiano
Alvarez Cienfuegos Suárez, José María
Cortés Ormazabal, Jesús
Research Group
Teoría de la señal y comunicaciones
Published Date
2021
Publisher
IEEE
Keywords
Pain
Electroencephalography
Heating systems
Biomedical monitoring ... [+]
Pain
Electroencephalography
Heating systems
Biomedical monitoring
Physiology
temperature measurement
Entropy [-]
Abstract
Objective: To develop a new device for identifying physiological markers of pain perception by reading the brain's electrical activity and hemodynamic interactions while applying thermoalgesic stimula ... [+]
Objective: To develop a new device for identifying physiological markers of pain perception by reading the brain's electrical activity and hemodynamic interactions while applying thermoalgesic stimulation. Methods: We designed a compact prototype that generates well-controlled thermal stimuli using a computer-driven Peltier cell while simultaneously capturing electroencephalography (EEG) and photoplethysmography (PPG) signals. The study was performed on 35 healthy subjects (mean age 30.46 years, SD 4.93 years; 20 males, 15 females). We first determined the heat pain threshold (HPT) for each subject, defined as the maximum temperature that the subject can withstand when the Peltier cell gradually increased the temperature. Next, we defined the painful condition as the one occurring at temperature equal to 90% of the HPT, comparing this to the no-pain state (control) in the absence of thermoalgesic stimulation. Results: Both the one-dimensional and the two-dimensional spectral entropy (SE) obtained from both the EEG and PPG signals differentiated the condition of pain. In particular, the SE for PPG was significantly reduced in association with pain, while the SE for EEG increased slightly. Moreover, significant discrimination occurred within a specific range of frequencies, 26-30 Hz for EEG and about 5-10 Hz for PPG. Conclusion: Hemodynamics, brain dynamics and their interactions can discriminate thermal pain perception. Significance: The possibility of monitoring on-line variations in thermal pain perception using a similar device and algorithms may be of interest to study different pathologies that affect the peripheral nervous system, such as small fiber neuropathies, fibromyalgia or painful diabetic neuropathy. [-]
URI
https://hdl.handle.net/20.500.11984/5599
Publisher’s version
https://doi.org/10.1109/JBHI.2021.3080935
ISSN
2168-2194
Published at
IEEE Journal of Biomedical and Health Informatics  Vol. 25. N. 8. P.p. 2948-2957, 2021
Document type
Article
Version
Submitted
Rights
© 2021 IEEE
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