Simple record

dc.rights.licenseAttribution 4.0 International*
dc.contributor.authorRomero-Bascones, David
dc.contributor.authorAyala, Unai
dc.contributor.authorAlberdi Aramendi, Ane
dc.contributor.authorErramuzpe Aliaga, Asier
dc.contributor.authorBarrenechea, Maitane
dc.contributor.otherGaldós, Marta
dc.contributor.otherGómez Esteban, Juan Carlos
dc.contributor.otherMurueta Goyena, Ane
dc.contributor.otherTeijeira, Sara
dc.contributor.otherGabilondo, Iñigo
dc.date.accessioned2023-01-16T11:10:48Z
dc.date.available2023-01-16T11:10:48Z
dc.date.issued2022
dc.identifier.issn1932-6203en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=170582en
dc.identifier.urihttps://hdl.handle.net/20.500.11984/5956
dc.description.abstractCharacterizing the effect of age and sex on macular retinal layer thicknesses and foveal pit morphology is crucial to differentiating between natural and disease-related changes. We applied advanced image analysis techniques to optical coherence tomography (OCT) to: 1) enhance the spatial description of age and sex effects, and 2) create a detailed open database of normative retinal layer thickness maps and foveal pit shapes. The maculae of 444 healthy subjects (age range 21–88) were imaged with OCT. Using computational spatial data analysis, thickness maps were obtained for retinal layers and averaged into 400 (20 x 20) sectors. Additionally, the geometry of the foveal pit was radially analyzed by computing the central foveal thickness, rim height, rim radius, and mean slope. The effect of age and sex on these parameters was analyzed with multiple regression mixed-effects models. We observed that the overall age-related decrease of the total retinal thickness (TRT) (-1.1% per 10 years) was mainly driven by the ganglion cell-inner plexiform layer (GCIPL) (-2.4% per 10 years). Both TRT and GCIPL thinning patterns were homogeneous across the macula when using percentual measurements. Although the male retina was 4.1 μm thicker on average, the greatest differences were mainly present for the inner retinal layers in the inner macular ring (up to 4% higher TRT than in the central macula). There was an age-related decrease in the rim height (1.0% per 10 years) and males had a higher rim height, shorter rim radius, and steeper mean slope. Importantly, the radial analysis revealed that these changes are present and relatively uniform across angular directions. These findings demonstrate the capacity of advanced analysis of OCT images to enhance the description of the macula. This, together with the created dataset, could aid the development of more accurate diagnosis models for macular pathologies.en
dc.description.sponsorshipGobierno Vasco-Eusko Jaurlaritzaes
dc.language.isoengen
dc.publisherPLoSen
dc.rights© 2022 The Authorsen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleSpatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphologyen
dcterms.accessRightshttp://purl.org/coar/access_right/c_abf2en
dcterms.sourcePLoS ONEen
local.contributor.groupTeoría de la señal y comunicacioneses
local.description.peerreviewedtrueen
local.identifier.doihttps://doi.org/10.1371/journal.pone.0278925en
local.relation.projectIDinfo:eu-repo/grantAgreement/GV/Ayudas a proyectos de investigación y desarrollo en salud 2020/2020333033/CAPV/Aplicación clínica de la inteligencia artificial sobre imágenes de OCT de retina para la clasificación precoz y monitorización de pacientes con enfermedad de Parkinson/OCTen
local.rights.publicationfeeAPCen
local.rights.publicationfeeamount1805 USDen
local.contributor.otherinstitutionhttps://ror.org/03nzegx43es
local.contributor.otherinstitutionhttps://ror.org/0061s4v88en
local.contributor.otherinstitutionhttps://ror.org/000xsnr85eu
local.contributor.otherinstitutionhttps://ror.org/01cc3fy72en
local.source.detailsVol. 17. N. 12. N. artículo e0278925.en
oaire.format.mimetypeapplication/pdf
oaire.file$DSPACE\assetstore
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501en
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85en


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Simple record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International