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dc.contributor.authorZabala, Alaitz
dc.contributor.otherLafuente-Merchan, Markel
dc.contributor.otherGalvez Martin, Patricia
dc.contributor.otherMarchal, Juan Antonio
dc.contributor.otherVázquez-Lasa, Blanca
dc.contributor.otherGallego, Idoia
dc.contributor.otherSáenz-del-Burgo, Laura
dc.contributor.otherPedraz, José Luis
dc.date.accessioned2022-02-16T15:22:27Z
dc.date.available2022-02-16T15:22:27Z
dc.date.issued2022
dc.identifier.issn1616-5195en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=167034en
dc.identifier.urihttps://hdl.handle.net/20.500.11984/5471
dc.description.abstractCartilage is a connective tissue which a limited capacity for healing and repairing. In this context, osteoarthritis (OA) disease may be developed with high prevalence in which the use of scaffolds may be a promising treatment. In addition, three-dimensional (3D) bioprinting has become an emerging additive manufacturing technology because of its rapid prototyping capacity and the possibility of creating complex structures. This study is focused on the development of nanocellulose-alginate (NC-Alg) based bioinks for 3D bioprinting for cartilage regeneration to which it is added chondroitin sulfate (CS) and dermatan sulfate (DS). First, rheological properties are evaluated. Then, sterilization effect, biocompatibility, and printability on developed NC-Alg-CS and NC-Alg-DS inks are evaluated. Subsequently, printed scaffolds are characterized. Finally, NC-Alg-CS and NC-Alg-DS inks are loaded with murine D1-MSCs-EPO and cell viability and functionality, as well as the chondrogenic differentiation ability are assessed. Results show that the addition of both CS and DS to the NC-Alg ink improves its characteristics in terms of rheology and cell viability and functionality. Moreover, differentiation to cartilage is promoted on NC-Alg-CS and NC-Alg-DS scaffolds. Therefore, the utilization of MSCs containing NC-Alg-CS and NC-Alg-DS scaffolds may become a feasible tissue engineering approach for cartilage regeneration.en
dc.language.isoengen
dc.publisherWileyen
dc.rights© 2022 Wileyen
dc.titleChondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage Regenerationen
dcterms.accessRightshttp://purl.org/coar/access_right/c_f1cfen
dcterms.sourceMacromolecular Bioscienceen
local.contributor.groupTecnologías de superficieses
local.description.peerreviewedtrueen
local.identifier.doihttps://doi.org/10.1002/mabi.202100435en
local.embargo.enddate2023-01-31
local.contributor.otherinstitutionhttps://ror.org/000xsnr85es
local.contributor.otherinstitutionhttps://ror.org/057p4eb38es
local.contributor.otherinstitutionhttps://ror.org/04njjy449es
local.contributor.otherinstitutionBiomaterials and Nanomedicine (CIBER-BBN)es
local.contributor.otherinstitutionInstituto de Investigación Sanitaria Bioarabaes
local.contributor.otherinstitutionhttps://ror.org/00bzgd159es
local.source.detailsEarly View. N. artículo 2100435, 2022en
oaire.format.mimetypeapplication/pdf
oaire.file$DSPACE\assetstore
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501en
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aaen


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