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dc.contributor.authorZabala, Alaitz
dc.contributor.otherLafuente Merchan, M.
dc.contributor.otherRuiz Alonso, S.
dc.contributor.otherEspona Noguera, A.
dc.contributor.otherGalvez Martin, Patricia
dc.contributor.otherLópez Ruiz, E.
dc.contributor.otherMarchal, J.A.
dc.contributor.otherLópez Donaire, M.L.
dc.contributor.otherCiriza, J.
dc.contributor.otherSaenz del Burgo, L.
dc.contributor.otherPedraz, J.L.
dc.date.accessioned2022-11-11T09:41:52Z
dc.date.available2022-11-11T09:41:52Z
dc.date.issued2021
dc.identifier.issn0928-4931en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=163591en
dc.identifier.urihttps://hdl.handle.net/20.500.11984/5835
dc.description.abstract3D-bioprinting is an emerging technology of high potential in tissue engineering (TE), since it shows effective control over scaffold fabrication and cell distribution. Biopolymers such as alginate (Alg), nanofibrillated cellulose (NC) and hyaluronic acid (HA) offer excellent characteristics for use as bioinks due to their excellent biocompatibility and rheological properties. Cell incorporation into the bioink requires sterilisation assurance, and autoclave, β-radiation and γ-radiation are widely used sterilisation techniques in biomedicine; however, their use in 3D-bioprinting for bioinks sterilisation is still in their early stages. In this study, different sterilisation procedures were applied on NC-Alg and NC-Alg-HA bioinks and their effect on several parameters was evaluated. Results demonstrated that NC-Alg and NC-Alg-HA bioinks suffered relevant rheological and physicochemical modifications after sterilisation; yet, it can be concluded that the short cycle autoclave is the best option to sterilise both NC-Alg based cell-free bioinks, and that the incorporation of HA to the NC-Alg bioink improves its characteristics. Additionally, 3D scaffolds were bioprinted and specifically characterized as well as the D1 mesenchymal stromal cells (D1-MSCs) embedded for cell viability analysis. Notably, the addition of HA demonstrates better scaffold properties, together with higher biocompatibility and cell viability in comparison with the NC-Alg scaffolds. Thus, the use of MSCs containing NC-Alg based scaffolds may become a feasible tissue engineering approach for regenerative medicine.en
dc.description.sponsorshipGobierno Vasco-Eusko Jaurlaritzaes
dc.description.sponsorshipGobierno de Españaes
dc.language.isoengen
dc.publisherElsevieren
dc.rights© 2021 Elsevier Ltden
dc.subject3D-bioprintingen
dc.subjectSterilisationen
dc.subjectbioinksen
dc.subjecttissue engineeringen
dc.titleDevelopment, characterization and sterilisation of Nanocellulose-alginate-(hyaluronic acid)- bioinks and 3D bioprinted scaffolds for tissue engineeringen
dcterms.accessRightshttp://purl.org/coar/access_right/c_f1cfen
dcterms.sourceMaterials Science and Engineering Cen
local.contributor.groupTecnologías de superficieses
local.description.peerreviewedtrueen
local.identifier.doihttps://doi.org/10.1016/j.msec.2021.112160en
local.relation.projectIDinfo:eu-repo/grantAgreement/GV/Ayudas para apoyar las actividades de grupos de investigación del sistema universitario vasco Grupos Consolidados (EHU)/IT907-16/CAPV//en
local.relation.projectID.en
local.embargo.enddate2023-07-31
local.contributor.otherinstitutionhttps://ror.org/000xsnr85es
local.contributor.otherinstitutionhttps://ror.org/01gm5f004es
local.contributor.otherinstitutionBioarabaes
local.contributor.otherinstitutionhttps://ror.org/057p4eb38es
local.contributor.otherinstitutionhttps://ror.org/04njjy449es
local.contributor.otherinstitutionhttps://ror.org/0122p5f64es
local.contributor.otherinstitutionhttps://ror.org/00bzgd159es
local.source.detailsVol. 126. N. artículo 112160. July, 2021en
oaire.format.mimetypeapplication/pdf
oaire.file$DSPACE\assetstore
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501en
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aaen


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