Título
Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson DiseaseAutor-a (de otra institución)
Otras instituciones
BioCruces Health Research InstituteIkerbasque
University College London
Moorfields Eye Hospital NHS Foundation Trust
Institute of Ophthalmology
Scripps Research
Stanford University
Queen Square Institute of Neurology
Great Ormond Street Hospital
Great Ormond Street Institute of Child Health
University Hospitals Birmingham
University of Birmingham
Versión
Version publicada
Derechos
© 2023 The AuthorsAcceso
Acceso abiertoVersión del editor
https://doi.org/10.1212/WNL.0000000000207727Publicado en
Neurology Vol. 101. N. 16Editor
American Journal of AnalogyPalabras clave
ODS 3 Salud y bienestarResumen
Background and Objectives
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it re ... [+]
Background and Objectives
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected with in vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), in prevalent PD and subsequently assessed the association of these markers with the development of PD using a prospective research cohort.
Methods
This cross-sectional analysis used data from 2 studies. For the detection of retinal markers in prevalent PD, we used data from AlzEye, a retrospective cohort of 154,830 patients aged 40 years and older attending secondary care ophthalmic hospitals in London, United Kingdom, between 2008 and 2018. For the evaluation of retinal markers in incident PD, we used data from UK Biobank, a prospective population-based cohort where 67,311 volunteers aged 40–69 years were recruited between 2006 and 2010 and underwent retinal imaging. Macular retinal nerve fiber layer (mRNFL), ganglion cell–inner plexiform layer (GCIPL), and inner nuclear layer (INL) thicknesses were extracted from fovea-centered OCT. Linear mixed-effects models were fitted to examine the association between prevalent PD and retinal thicknesses. Hazard ratios for the association between time to PD diagnosis and retinal thicknesses were estimated using frailty models.
Results
Within the AlzEye cohort, there were 700 individuals with prevalent PD and 105,770 controls (mean age 65.5 ± 13.5 years, 51.7% female). Individuals with prevalent PD had thinner GCIPL (−2.12 μm, 95% CI −3.17 to −1.07, p = 8.2 × 10−5) and INL (−0.99 μm, 95% CI −1.52 to −0.47, p = 2.1 × 10−4). The UK Biobank included 50,405 participants (mean age 56.1 ± 8.2 years, 54.7% female), of whom 53 developed PD at a mean of 2,653 ± 851 days. Thinner GCIPL (hazard ratio [HR] 0.62 per SD increase, 95% CI 0.46–0.84, p = 0.002) and thinner INL (HR 0.70, 95% CI 0.51–0.96, p = 0.026) were also associated with incident PD.
Discussion
Individuals with PD have reduced thickness of the INL and GCIPL of the retina. Involvement of these layers several years before clinical presentation highlight a potential role for retinal imaging for at-risk stratification of PD. [-]
Colecciones
- Artículos - Ingeniería [639]
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