Izenburua
Sentinel Node Biopsy Imaging in Breast Cancer Scatter Reduction Using 3-Dimensionally Printed Lead ShieldsEgilea
Egilea (beste erakunde batekoa)
Beste instituzio
Hospital Universitario Puerta del MarVietTin Land Investment and Consultant
University of Southern California
International Atomic Energy Agency
Centre Léon Bérard
Bertsioa
Bertsio argitaratua
Eskubideak
© 2022 The AuthorsSarbidea
Sarbide irekiaArgitaratzailearen bertsioa
https://doi.org/10.1097/RLU.0000000000004274Non argitaratua
Clinical Nuclear Medicine Vol. 47. N. 7. P.p. 618-624,Lehenengo orria
618Azken orria
624Argitaratzailea
Wolters KluwerGako-hitzak
Breast cancer
lead shield
lymphoscintigraphy
scatter ... [+]
lead shield
lymphoscintigraphy
scatter ... [+]
Breast cancer
lead shield
lymphoscintigraphy
scatter
sentinel lymph node
sentinel node biopsy [-]
lead shield
lymphoscintigraphy
scatter
sentinel lymph node
sentinel node biopsy [-]
Laburpena
Background
Point of injection scatter (SPI) confounds breast cancer sentinel lymph node detection. Round flat lead shields (FLSs) incompletely reduce SPI, requiring repositioning. We designed lead s ... [+]
Background
Point of injection scatter (SPI) confounds breast cancer sentinel lymph node detection. Round flat lead shields (FLSs) incompletely reduce SPI, requiring repositioning. We designed lead shields that reduce SPI and acquisition time.
Methods
Two concave lead shields, a semioval lead shield (OLS) and a semispherical lead alloy shield (SLS), were created with a SICNOVA JCR 1000 3D printer to cover the point of injection (patent no. ES1219895U). Twenty breast cancer patients had anterior and anterior oblique imaging, 5 minutes and 2 hours after a single 111 MBq nanocolloid in 0.2 mL intratumoral or periareolar injection. Each acquisition was 2 minutes. Absolute and normalized background corrected scatter counts (CSCs) and scatter reduction percentage (%SR) related to the FLS were calculated. Repositionings were recorded. Differences between means of %SR (t test) and between means of CSC (analysis of variance) with Holm multiple comparison tests were determined.
Results
Mean %SR was 91.8% with OLS and 92% using SLS in early images (P = 0.91) and 87.2%SR in OLS and 88.5% in late images (P = 0.66). There were significant differences between CSC using FLS and OLS (P < 0.001) and between FLS and SLS (P < 0.001), but not between OLS and SLS (P = 0.17) in early images, with the same results observed in delayed studies (P < 0.001 in relation to FLS and P = 0.1 between both curved lead shields). Repositioning was required 14/20 times with FLS, 4/20 times with OLS, and 2/20 times with SLS.
Conclusions
We designed 2 concave lead shields that significantly reduce the SPI and repositioning with sentinel lymph node lymphoscintigraphy. [-]
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