2026-04-10T14:27:17Zhttps://ebiltegia.mondragon.edu/oai/request

oai:ebiltegia.mondragon.edu:20.500.11984/70012025-05-14T06:15:31Zcom_20.500.11984_473col_20.500.11984_478

00925njm 22002777a 4500 dc Buruaga, Lorea author Pomposo, José A. author 2011 “Click” chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis of ultra-small (7 nm in size) polymethyl methacrylate (PMMA) nanoparticles (NPs) by the “metal-free” cross-linking of PMMA-precursor chains prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization containing β-ketoester functional groups. Intramolecular collapse was performed by the one-pot reaction of β-ketoester moieties with alkyl diamines in tetrahydrofurane at r.t. (i.e., by enamine formation). The collapsing process was followed by size exclusion chromatography and by nuclear magnetic resonance spectroscopy. The size of the resulting PMMA-NPs was determined by dynamic light scattering. Enamine “click” chemistry increases the synthetic toolbox for the efficient synthesis of metal-free, ultra-small polymeric NPs. 2073-4360 https://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=128603 https://hdl.handle.net/20.500.11984/7001 Nanoparticles Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine “Click” Chemistry at Room Temperature