2026-04-21T16:18:43Zhttps://ebiltegia.mondragon.edu/oai/requestoai:ebiltegia.mondragon.edu:20.500.11984/61062024-03-04T14:20:54Zcom_20.500.11984_473col_20.500.11984_478
eBiltegia
author
Romero-Bascones, David
author
Ayala, Unai
other
Murueta Goyena, Ane
other
del Pino, Rocío
other
Acera, Marian
other
Teijeira‑Portas, Sara
other
Fernández‑Valle, Tamara
other
Tijero, Beatriz
other
Gabilondo, Iñigo
other
Gómez Esteban, Juan Carlos
2023-09-05T15:55:29Z
2023-09-05T15:55:29Z
2023
0340-5354
https://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=172728
https://hdl.handle.net/20.500.11984/6106
Background Cognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal layer thickness seems to be a good biomarker of cognition in other neurodegenerative diseases. Objective To explore the relationship between optical coherence tomography-derived metrics and global cognition in Huntington’s Disease.
Methods Thirty-six patients with Huntington’s disease (16 premanifest and 20 manifest) and 36 controls matched by age, sex, smoking status, and hypertension status underwent macular volumetric and peripapillary optical coherence tomography scans. Disease duration, motor status, global cognition and CAG repeats were recorded in patients. Group differences in imaging parameters and their association with clinical outcomes were analyzed using linear mixed-effect models.
Results Premanifest and manifest Huntington’s disease patients presented thinner retinal external limiting membrane-Bruch’s membrane complex, and manifest patients had thinner temporal peripapillary retinal nerve fiber layer compared to controls. In manifest Huntington’s disease, macular thickness was significantly associated with MoCA scores, inner nuclear layer showing the largest regression coefficients. This relationship was consistent after adjusting for age, sex, and education and p-value correction with False Discovery Rate. None of the retinal variables were related to Unified Huntington’s Disease Rating Scale score, disease duration, or disease burden. Premanifest patients did not show a significant association between OCT-derived parameters and clinical outcomes in corrected models.
Conclusions In line with other neurodegenerative diseases, OCT is a potential biomarker of cognitive status in manifest HD. Future prospective studies are needed to evaluate OCT as a potential surrogate marker of cognitive decline in HD.
eng
© Tha Author(s) 2023
Huntington's disease
retina
optical coherence tomography
cognition
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
http://purl.org/coar/resource_type/c_6501

EBILTEGIA-N, MONDRAGON UNIBERTSITATEKO GORDAILU IREKIAN, MATERIALAK UZTEKO ERABILERA LIZENTZIA ETA ESKUBIDEEN LAGAPEN EZ-ESKLUSIBOA

Gordailuan utzitako materialaren egile edo egile eskubideen titular naizen aldetik, Mondragon Unibertsitateari erabilera-baimena eta/edo LAGAPEN EZ-ESKLUSIBOA ematen diot, doan, mundu eremuan eta legezko gehieneko epean, material horren gaineko erreprodukzio, banaketa, komunikazio publiko –elektronikoki eskuragarri jartzeko eskubidea barne– eta eraldatzeko eskubideetarako, hirugarren batzuen esku jartzeko aukera emanez, gordailuan utzitako material horri lotutako dagokion lizentzian ezarritako erabilera baldintzen arabera.

ONARTZEN DUT Mondragon Unibertsitateak, edukia aldatu gabe, gordailuan utzitako materiala gordetzeko beharrezkoak diren beste formatu edo bitarteko batzuetara eraldatzea edo egokitzea. Era berean, ONARTZEN DUT Mondragon Unibertsitateak gordailuan utzitako materialaren kopia bat baino gehiago gordetzea, segurtasun kopiak egiteko eta materiala etorkizunerako gordetzeko.

ZIURTATZEN DUT eta BERMATZEN DUT gordailuan utzitako materiala nik sortutako jatorrizko obra dela, eta nik dudala Lizentzia honetan jasotako lagapena emateko beharrezko egile eskubidearen titulartasuna.

Titulartasuna partekatzen den kasuetan, onartzen dut gainerako titularren baimena dudala Lizentzia hau emateko. Eskubideak hirugarren batzuei aurrez lagata izanez gero, ZIURTATZEN dut haien baimena dudala edo lizentzia honetan aurrez ikusitako moduan eskubideak erabiltzeko gaitasuna mantentzen dudala.

Lagatako materialak egile eskubideen titular ez naizen bestelako material batzuk izango balitu, ZIURTATZEN DUT eta BERMATZEN DUT dagokion titularraren baimena lortu dudala aurrez Lizentzia hau eman ahal izateko eta, era berean, ZIURTATZEN DUT eta BERMATZEN dut gordailuan utzitako materialaren edukian behar bezala identifikatuta eta aitortuta dagoela egile eskubidearen titular hori.

Azken batean, ZIURTATZEN DUT eta BERMATZEN DUT eBiltegian gordailuan utzitako materialak EZ DUELA HAUSTEN hirugarren batzuen eskubiderik, ez jabetza intelektualekorik ez industrialekorik, ohore, intimitate eta irudi eskubiderik, edo bestelako edozein eskubiderik.

Gordailuan utzitako materiala Mondragon Unibertsitatea ez den beste agentzia edo erakunderen batek finantzatutako ikerketan oinarrituta baldin badago, ZIURTATZEN DUT eta BERMATZEN DUT bete ditudala erakunde horrekin sinatutako kontratuak edo akordioak eskatutako betebehar guztiak.

Mondragon Unibertsitateak konpromisoa hartzen du gordailuan utzitako materialaren egile edo egile eskubideen titular gisa zu identifikatzeko, eta ez du material horretan Lizentzia honek espresuki ahalbidetutakoa ez den aldaketarik egingo.

Gordailuan utzitako materialaren egile edo egile eskubideen titular zaren heinean, obra eBiltegitik kentzeko eska dezakezu justifikatutako arrazoi batekin. Horretarako, arduradunekin harremanetan jarri beharko duzu.

Era berean, eBiltegiak gordailuan utzitako materiala kendu ahal izango du behar bezala justifikatutako kasuetan edo jabetza intelektualeko eskubideei lotuta hirugarren batzuen erreklamaziorik jasoz gero. Bi kasuetan aurretiaz espresuki jakinaraziko da.


-------------------------------------------------------


LICENCIA DE USO Y CESIÓN DE DERECHOS NO EXCLUSIVA PARA EL DEPÓSITO DE MATERIALES EN EBILTEGIA, REPOSITORIO ABIERTO DE MONDRAGON UNIBERTSITATEA

Como autor/a o titular de los derechos de autor del material depositado otorgo a Mondragon Unibertsitatea la autorización de uso y/o CESIÓN NO EXCLUSIVA, gratuita, con ámbito mundial y por el plazo máximo legal, de los derechos de reproducción, distribución, comunicación pública ‒incluido el derecho de puesta a disposición electrónica‒ y transformación sobre dicho material, permitiendo ponerlo a disposición de terceros, en las condiciones de uso que se establezcan en la correspondiente licencia asociada a dicho material depositado.

ACEPTO que Mondragon Unibertsitatea pueda, sin alterar el contenido, transformar o adaptar el material depositado a cualquier otro formato o medio que resulte necesario con fines de preservación. Igualmente, ACEPTO que Mondragon Unibertsitatea pueda guardar más de una copia del material depositado a fin de realizar copias de seguridad y preservar el material para el futuro.

ASEGURO y GARANTIZO que el material depositado es una obra original de mi creación, sobre la que ostento la titularidad de derechos de autor necesaria para otorgar la cesión contenida en la presente Licencia.

En caso de cotitularidad admito contar con el consentimiento de los restantes titulares para otorgar la presente Licencia. En caso de previa cesión de derechos a terceros, ASEGURO contar con su autorización o retengo la facultad de hacer uso de estos derechos en la forma prevista en la presente licencia.

En el caso de que el material depositado contuviera otro material del que no soy el/la titular de los derechos de autor, ASEGURO y GARANTIZO haber obtenido la previa autorización del correspondiente titular que me permite otorgar la presente Licencia y, del mismo modo, ASEGURO y GARANTIZO que en el contenido del material depositado queda correctamente identificado y reconocido el dicho titular de derecho de autor.

En definitiva, ASEGURO y GARANTIZO que el material depositado en eBiltegia NO INFRINGE derecho alguno de terceros, ya sea de propiedad intelectual o industrial, derecho al honor, a la intimidad y a la imagen, o cualquier otro derecho.

En el caso de que el material depositado esté basado en una investigación financiada por alguna agencia u organismo distinto de Mondragon Unibertsitatea, ASEGURO y GARANTIZO haber cumplido con todas las obligaciones requeridas por el contrato o acuerdo firmado con dicho organismo.

Mondragon Unibertsitatea adquiere el compromiso de identificarte como autor/a o titular de derechos de autor del material depositado, y no efectuará más alteraciones en dicho material que las expresamente permitidas en esta Licencia.

Como autor/a o titular de derechos de autor del material depositado puedes solicitar la retirada de la obra de eBiltegia por causa justificada. Para ello deberás ponerse en contacto con las personas responsables del mismo.

De igual modo, eBiltegia podrá retirar el material depositado en supuestos suficientemente justificados o en caso de reclamaciones de terceros relativas a los derechos de propiedad intelectual. En ambos supuestos existirá una notificación expresa previa.


-------------------------------------------------------


NON-EXCLUSIVE LICENCE FOR THE USE AND ASSIGNMENT OF RIGHTS FOR SUBMISSIONS TO EBILTEGIA, THE OPEN REPOSITORY OF MONDRAGON UNIBERTSITATEA

As the author or holder of the copyright of the sumitted material, I hereby grant Mondragon Unibertsitatea the NON-EXCLUSIVE authorisation to use and/or ASSIGN, free of charge, worldwide and for the maximum legal term, the rights to reproduce, distribute, publish ‒ including the right to make it available in electronic format ‒ and convert such material, allowing it to be made available to third parties, subject to the terms of use set forth in the respective licence associated with the submitted material.

I hereby AUTHORISE Mondragon Unibertsitatea to convert or adapt the submitted material to any other format or medium that may be necessary for the purpose of its preservation, without changing its content. I also AUTHORISE Mondragon Unibertsitatea to keep more than one copy of the submitted material so that it may make back-ups and preserve the material for the future.

I WARRANT and REPRESENT that the material submitted is an original work created by me, and I hold the necessary copyright to grant the right of assignment contained in this Licence.

In the event of joint ownership of author’s rights, I warrant that I have the consent of the other copyright holders to grant this Licence. In the event of any prior assignment of the rights to third parties, I WARRANT that I have their authorisation or still have the faculty to use these rights in the manner set forth in this licence.

If the submitted material contains any other material for which I do not hold the copyright, I WARRANT and REPRESENT that I have obtained the prior authorisation of the respective copyright holder, which enables me to grant this Licence and, similarly, I WARRANT and REPRESENT that in the content of the submitted material, the copyright holder is duly identified and acknowledged.

In short, I WARRANT AND REPRESENT that the material submitted to eBiltegia DOES NOT INFRINGE any third-party rights, whether relates to intellectual or industrial property, right to honour, privacy or self-image, or any other right.

If the submitted material is based upon research sponsored or supportes by any agency or institution other than Mondragon Unibertsitatea, I WARRANT AND REPRESENT that I have fulfilled all obligations required by the contract or agreement signed with the institution.

Mondragon Unibertsitatea hereby agrees to identify you as the author or holder of the copyright of the submited material, and it shall make no changes to that material other than those expressly permitted by this Licence.

As the author or holder of the copyright for the submitted material, you may request that the work is removed from eBiltegia if there is good cause. In such an event, you must contact the persons responsible for doing this.

Similarly, eBiltegia may remove the submitted material when there is good cause or in the event of third-party claims regarding intellectual property rights. In both cases, express prior notification shall be given.

URL
http://ebiltegia.mondragon.edu/xmlui/bitstream/20.500.11984/6106/1/Retinal%20thickness%20as%20a%20biomarker%20of%20cognitive%20impairment%20in%20manifest.pdf
File
MD5
31ab3b25d4bdc2602db41eca383dee5a
827144
application/pdf
Retinal thickness as a biomarker of cognitive impairment in manifest.pdf
URL
http://ebiltegia.mondragon.edu/xmlui/bitstream/20.500.11984/6106/4/Retinal%20thickness%20as%20a%20biomarker%20of%20cognitive%20impairment%20in%20manifest.pdf.txt
File
MD5
6a0c5740b890f6e44e61e353c0d03a7e
39019
text/plain
Retinal thickness as a biomarker of cognitive impairment in manifest.pdf.txt