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Torca, Ireneo Esnaola, Jon Ander 2020-06-16T09:02:52Z 2020-06-16T09:02:52Z 2018 2040-3372 https://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=145617 https://hdl.handle.net/20.500.11984/1691 The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport. eng Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ © The Royal Society of Chemistry 2018 Membrane-containing virus particles exhibits mechanics of a composite material for genome protection http://purl.org/coar/resource_type/c_6501