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oai:ebiltegia.mondragon.edu:20.500.11984/16912024-03-04T15:05:51Zcom_20.500.11984_473col_20.500.11984_478

00925njm 22002777a 4500 dc Torca, Ireneo author Esnaola, Jon Ander author 2018 The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport. 2040-3372 https://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=145617 https://hdl.handle.net/20.500.11984/1691 Membrane-containing virus particles exhibits mechanics of a composite material for genome protection