2026-06-25T19:53:23Zhttps://ebiltegia.mondragon.edu/oai/request

oai:ebiltegia.mondragon.edu:20.500.11984/145962026-06-19T06:15:52Zcom_20.500.11984_473com_20.500.11984_14090col_20.500.11984_477

Epinephrine-Induced Reduction in Insulin Receptor mRNA Level and Stability in U-937 Human Promonocytic Cells Mas, Antonio Campion, Javier Aller, Patricio calle, consuelo Insulin Receptor Gene Expression Epinephrine U-937 Human Promonocytic Cells Insulin Receptor Isotypes The administration of 10-5 M epinephrine transiently decreased insulin receptor (IR) mRNA levels in U-937 human promonocytic cells, which reached their minimum value after 24 hours. Such a decrease seems to be due, at least in part, to a reduction in transcript stability, since the IR mRNA half-life was observed to decline from approximately 4 h in untreated cells to 3 h in epinephrine-treated cells. Computer inspection of the sequence of the 3′ untranslated region of the human IR mRNA showed nine AUUUA pentamers and three U-rich regions. These domains could be targets for a RNA-binding protein induced by treatment with epinephrine producing a destabilization of IR mRNA in U-937 cells. 2026-06-18T11:28:31Z 2026-06-18T11:28:31Z 1998 439-4286 https://hdl.handle.net/20.500.11984/14596 eng © Georg Thieme Verlag Thieme E-Journals