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00925njm 22002777a 4500 dc Campion, Javier author Aller, Patricio author dávila, norma author Carranza, María del Carmen author de miguel, rosario author calle, consuelo author 1997-04 Insulin receptor (IR) gene expression at the mRNA level was investigated in liver, hindlimb skeletal muscle, and epididymal adipose tissue of rats exposed to prolonged in vivo administration of adrenaline in relation to control rats. In the liver of adrenalinetreated rats, there were no differences in relation to controls when DNA and protein content were measured. In skeletal muscle, only a slight decrease in protein concentration was detected. By contrast, a clear increase in both protein and DNA content was observed in the adipose tissue of treated animals. Northern blot assays revealed two IR mRNA species of approximately 9.5 and 7.5 Kb in the three tissues from controls. Adrenaline treatment induced an increase of approximately 60% in the levels of both RNAs in adipose tissue but not in liver or skeletal muscle. These results provide evidence for an in vivo tissue-specific regulation of IR gene expression at the mRNA level in rats under an experimental condition of excess of catecholamines 1573-4919 https://hdl.handle.net/20.500.11984/14579 Insulin receptor gene expression adrenaline-treated rats Tissue-specific modulation of insulin receptor mRNA levels in adrenaline-treated rats