2026-07-09T10:38:24Zhttps://ebiltegia.mondragon.edu/oai/request

oai:ebiltegia.mondragon.edu:20.500.11984/145282026-06-12T06:15:39Zcom_20.500.11984_473com_20.500.11984_14090col_20.500.11984_477

00925njm 22002777a 4500 dc Galbete, Cecilia author Contreras, Rafael author Martinez, J. Alfredo author Martínez-González, Miguel Ángel author Guillen-Grima, FRANCISCO author Marti del Moral, Amelia author 2012 Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle factors in an elderly population of the SUN Project. Subjects (n=903, aged 69±6) were recruited from the SUN (“Seguimiento Universidad de Navarra”) Project. DNA was obtained from saliva and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. A significant interaction between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk was observed (p for interaction [Sex*CLOCK] interaction <0.001). Our results showed that women carrying the C allele of CLOCK gene had a decreased overweight/obesity risk compared to non carrier -TT- subjects (OR 0.61, 95% CI: 0.36-1.04, p=0.069). Moreover, the protective effect of the 3111T/C gene variant may be enhanced in those women with a high physical activity practice. We found that women practicing more than 16.8 METs- h/week had a significantly lower overweight/obesity risk (OR 0.36, 95%CI: 0.17-0.79, p=0.011). A significant interaction between the 3111T/C gene variant and physical activity for overweight/obesity risk was observed in women (p for [PA x CLOCK] interaction=0.015). In conclusion, it appears that physical activity levels may act as an effect modifier for overweight/obesity risk linked to the 3111T/C SNP (rs1801260) of the CLOCK gene in an elderly population of the SUN Project. 0742-0528 https://hdl.handle.net/20.500.11984/14528 CLOCK rs1801260 Cross-sectional study Obesity risk Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project