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dc.contributor.authorRomero-Bascones, David
dc.contributor.otherWagner, Siegfried K.
dc.contributor.otherCortina Borja, Mario
dc.contributor.otherSilverstein, Steven M.
dc.contributor.otherZhou, Yukun
dc.contributor.otherStruyven, Robbert R.
dc.contributor.otherTrucco, Emanuele
dc.contributor.otherMookiah, Muthu R. K.
dc.contributor.otherMacGillivray, Tom
dc.contributor.otherHogg, Stephen
dc.contributor.otherLiu, Timing
dc.contributor.otherWilliamson, Dominic J.
dc.contributor.otherPontikos, Nikolas
dc.contributor.otherPatel, Praveen J.
dc.contributor.otherBalaskas, Konstantinos
dc.contributor.otherAlexander, Daniel C.
dc.contributor.otherStuart, Kelsey V.
dc.contributor.otherKhawaja, Anthony P.
dc.contributor.otherDenniston, Alastair K.
dc.contributor.otherRahi, Jugnoo S.
dc.contributor.otherPetzold, Axel
dc.contributor.otherKeane, Pearse A.
dc.date.accessioned2023-03-23T13:48:58Z
dc.date.available2023-03-23T13:48:58Z
dc.date.issued2023
dc.identifier.issn2168-6238en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=171985en
dc.identifier.urihttps://hdl.handle.net/20.500.11984/6060
dc.description.abstractImportance. The potential association of schizophrenia with distinct retinal changes is of clinical interest but has been challenging to investigate because of a lack of sufficiently large and detailed cohorts. Objective. To investigate the association between retinal biomarkers from multimodal imaging (oculomics) and schizophrenia in a large real-world population. Design, Setting, and Participants This cross-sectional analysis used data from a retrospective cohort of 154 830 patients 40 years and older from the AlzEye study, which linked ophthalmic data with hospital admission data across England. Patients attended Moorfields Eye Hospital, a secondary care ophthalmic hospital with a principal central site, 4 district hubs, and 5 satellite clinics in and around London, United Kingdom, and had retinal imaging during the study period (January 2008 and April 2018). Data were analyzed from January 2022 to July 2022. Main Outcomes and Measures. Retinovascular and optic nerve indices were computed from color fundus photography. Macular retinal nerve fiber layer (RNFL) and ganglion cell–inner plexiform layer (mGC-IPL) thicknesses were extracted from optical coherence tomography. Linear mixed-effects models were used to examine the association between schizophrenia and retinal biomarkers. Results. A total of 485 individuals (747 eyes) with schizophrenia (mean [SD] age, 64.9 years [12.2]; 258 [53.2%] female) and 100 931 individuals (165 400 eyes) without schizophrenia (mean age, 65.9 years [13.7]; 53 253 [52.8%] female) were included after images underwent quality control and potentially confounding conditions were excluded. Individuals with schizophrenia were more likely to have hypertension (407 [83.9%] vs 49 971 [48.0%]) and diabetes (364 [75.1%] vs 28 762 [27.6%]). The schizophrenia group had thinner mGC-IPL (−4.05 μm, 95% CI, −5.40 to −2.69; P = 5.4 × 10−9), which persisted when investigating only patients without diabetes (−3.99 μm; 95% CI, −6.67 to −1.30; P = .004) or just those 55 years and younger (−2.90 μm; 95% CI, −5.55 to −0.24; P = .03). On adjusted analysis, retinal fractal dimension among vascular variables was reduced in individuals with schizophrenia (−0.14 units; 95% CI, −0.22 to −0.05; P = .001), although this was not present when excluding patients with diabetes. Conclusions and Relevance. In this study, patients with schizophrenia had measurable differences in neural and vascular integrity of the retina. Differences in retinal vasculature were mostly secondary to the higher prevalence of diabetes and hypertension in patients with schizophrenia. The role of retinal features as adjunct outcomes in patients with schizophrenia warrants further investigation.en
dc.language.isoengen
dc.publisherJAMA Networken
dc.rights© 2023 American Medical Associationen
dc.subjectPsychiatry and Behavioral Healthen
dc.subjectSchizophrenia Spectrum and Other Psychotic Disordersen
dc.subjectOphthalmologyen
dc.subjectRetinal Disordersen
dc.subjectRadiologyen
dc.subjectOphthalmic Imagingen
dc.subjectODS 3 Salud y bienestares
dc.titleAssociation Between Retinal Features From Multimodal Imaging and Schizophreniaen
dcterms.sourceJAMA Psychiatryen
local.contributor.groupTeoría de la señal y comunicacioneses
local.description.peerreviewedtrueen
local.identifier.doihttp://doi.org/10.1001/jamapsychiatry.2023.0171en
local.contributor.otherinstitutionhttps://ror.org/004hydx84en
local.contributor.otherinstitutionhttps://ror.org/02jx3x895en
local.contributor.otherinstitutionhttps://ror.org/03zaddr67en
local.contributor.otherinstitutionhttps://ror.org/022kthw22en
local.contributor.otherinstitutionhttps://ror.org/03h2bxq36en
local.contributor.otherinstitutionhttps://ror.org/01nrxwf90en
local.contributor.otherinstitutionhttps://ror.org/014ja3n03en
local.contributor.otherinstitutionhttps://ror.org/03angcq70en
local.contributor.otherinstitutionhttps://ror.org/03zydm450en
local.contributor.otherinstitutionNIHR Biomedical Research Centreen
oaire.format.mimetypeapplication/pdfen
oaire.file$DSPACE\assetstoreen
oaire.licenseConditionhttp://purl.org/coar/access_right/c_abf2en
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501en
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aaen


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