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dc.rights.licenseAttribution 4.0 International*
dc.contributor.authorErramuzpe Aliaga, Asier
dc.contributor.otherIñiguez, Martin
dc.contributor.otherJiménez-Marín, Antonio
dc.contributor.otherAcera, Marian
dc.contributor.otherMurueta Goyena, Ane
dc.contributor.otherdel Pino, Rocío
dc.contributor.otherFernández, Tamara
dc.contributor.otherCarmona, Mar
dc.contributor.otherCabrera-Zubizarreta, Alberto
dc.contributor.otherGómez Esteban, Juan Carlos
dc.contributor.otherCortés, Jesús M.
dc.contributor.otherGabilondo, Iñigo
dc.date.accessioned2022-11-10T09:55:31Z
dc.date.available2022-11-10T09:55:31Z
dc.date.issued2022
dc.identifier.issn2373-8057en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=167846en
dc.identifier.urihttps://hdl.handle.net/20.500.11984/5820
dc.description.abstractHeart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization between HRV and brain activity in 31 PD patients and 21 age-matched healthy controls using blood-oxygen-level-dependent (BOLD) signals from resting-state functional brain MRI and HRV metrics from finger plethysmography recorded for 7.40 min. We additionally quantified autonomic symptoms (SCOPA-AUT) and objective autonomic cardiovascular parameters (blood pressure and heart rate) during deep breathing, Valsalva, and head-up tilt, which were used to classify the clinical severity of dysautonomia. We evaluated HRV and BOLD signals synchronization (HRV-BOLD-sync) with Pearson lagged cross-correlations and Fisher’s statistics for combining window-length-dependent HRV-BOLD-Sync Maps and assessed their association with clinical dysautonomia. HRV-BOLD-sync was lower significantly in PD than in controls in various brain regions within CAN or in networks involved in autonomic modulation. Moreover, heart-brain synchronization index (HBSI), which quantifies heart-brain synchronization at a single-subject level, showed an inverse exposure–response relationship with dysautonomia severity, finding the lowest HBSI in patients with severe dysautonomia, followed by moderate, mild, and, lastly, controls. Importantly, HBSI was associated in PD, but not in controls, with Valsalva pressure recovery time (sympathetic), deep breathing E/I ratio (cardiovagal), and SCOPA-AUT. Our findings support the existence of heart-brain de-synchronization in PD with an impact on clinically relevant autonomic outcomes.es
dc.description.sponsorshipMichael J. Fox Foundationen
dc.description.sponsorshipInstituto de Salud Carlos IIIes
dc.language.isoengen
dc.publisherSpringer Natureen
dc.rights© 2022 The Authorsen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleHeart-brain synchronization breakdown in Parkinson’s diseaseen
dcterms.accessRightshttp://purl.org/coar/access_right/c_abf2en
dcterms.sourcenpj Parkinson's Diseaseen
local.contributor.groupTeoría de la señal y comunicacioneses
local.description.peerreviewedtrueen
local.identifier.doihttps://doi.org/10.1038/s41531-022-00323-wen
local.contributor.otherinstitutionhttps://ror.org/03ths8210es
local.contributor.otherinstitutionBernstein Center for Computational Neuroscienceen
local.contributor.otherinstitutionhttps://ror.org/0061s4v88en
local.contributor.otherinstitutionhttps://ror.org/000xsnr85es
local.contributor.otherinstitutionOsatekeu
local.contributor.otherinstitutionhttps://ror.org/01cc3fy72en
local.source.detailsVol. 8. Artículo 64. May, 2022en
oaire.format.mimetypeapplication/pdf
oaire.file$DSPACE\assetstore
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501en
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85en


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Registro sencillo

Attribution 4.0 International
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