Zerrendatu Artikuluak-Gastronomia honen arabera: argitalpen data
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Tissue-specific modulation of insulin receptor mRNA levels in adrenaline-treated rats
(Springer Nature Link, 1997-04)Insulin receptor (IR) gene expression at the mRNA level was investigated in liver, hindlimb skeletal muscle, and epididymal adipose tissue of rats exposed to prolonged in vivo administration of adrenaline in relation to ... -
In vivo tissue specific modulation of rat insulin receptor gene expression in an experimental model of mineralocorticoid excess
(Springer Nature Link, 1998)Insulin receptor (IR) gene expression at the mRNA level was investigated in hindlimb skeletal muscle, epididymal adipose tissue and in the liver of rats exposed to prolonged in vivo administration of deoxycorticosterone ... -
Epinephrine-Induced Reduction in Insulin Receptor mRNA Level and Stability in U-937 Human Promonocytic Cells
(Thieme E-Journals, 1998)The administration of 10-5 M epinephrine transiently decreased insulin receptor (IR) mRNA levels in U-937 human promonocytic cells, which reached their minimum value after 24 hours. Such a decrease seems to be due, at least ... -
Inhibition by aldosterone of insulin receptor mRNA levels and insulin binding in U-937 human promonocytic cells
(Elsevier, 1999)The effect of aldosterone on insulin receptor (IR) expression was investigated in U-937 human promonocytic cells. The putative involvement of the mineralocorticoid receptor (MR) was also analysed. Aldosterone binding assays ... -
Aldosterone impairs insulin responsiveness in U-937 human promonocytic cells via the downregulation of its own receptor
(John Wiley & Sons, Ltd, 2002)n an earlier study, we have reported an inhibition of insulin receptor (IR) mRNA levels and insulin binding by aldosterone in U-937 human promonocytic cells. In the present extension of our studies, we demonstrate that ... -
Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1 Available to Purchase
(Biochemical society, 2003)Glucocorticoid (GC) signalling influences the response of the cell to a number of other signals via a mechanism referred to as ‘cross-talk'. This cross-talk may act at several levels, including an interaction between the ... -
Ketoconazole, an Antifungal Agent, Protects Against Adiposity Induced by a Cafeteria Diet
(2004)Ketoconazole, an anti-glucocorticoid agent, is widely used in humans as an antifungal agent. It inhibits ergosterol synthesis and reduces cortisol levels in the treatment of Cushing’s Syndrome. The aim of this work was to ... -
Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity
(Springer Nature Link, 2006)Obesity is considered as an inflammatory disease, in which free radical-induced oxidative stress and excessive intake of macronutrients exacerbate their symptoms. In this context, we assessed in rats the possible preventive ... -
Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers
(Springer Nature Link, 2007)It has been reported that apelin functions as an adipokine, which has been associated to obesity and insulin resistance. The objective of this study was to analyze the apelin mRNA expression in white adipose tissue ... -
11-β Hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity
(Elsevier, 2007)Glucocorticoid action within the cells is regulated by the levels of glucocorticoid receptor (GR) expression and two enzymes, 11-β hydroxysteroid dehydrogenase type 1 (11βHSD1), which converts inactive to active glucocorticoids, ... -
Vitamin C Supplementation Influences Body Fat Mass and Steroidogenesis-Related Genes when Fed a High-Fat Diet
(Hogrefe AG, 2008)An enhanced oxidative stress status has been documented in obese patients and animal models, and a depletion of the antioxidant mechanisms in these conditions is a common feature. Therefore, we have tested the hypothesis ... -
The effect of the Mediterranean diet on plasma brain-derived neurotrophic factor (BDNF) levels: The PREDIMED-NAVARRA randomized trial
(Taylor & Francis, 2011)Objectives There are no human studies assessing the effect of nutritional interventions on plasma brain-derived neurotrophic factor (BDNF) concentrations. The aim of this study was to assess the role of a nutritional ... -
Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project
(Taylor & Francis, 2012)Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the effect of rs1801260 SNP (3111T/C) of CLOCK gene, on obesity risk and to examine their interaction with lifestyle ... -
Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: A cross-sectional analysis in the SUN Project
(Springer Nature Link, 2012)Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk ... -
Weight gain induced by high-fat feeding involves increased liver oxidative stress
(John Wiley & Sons, Ltd, 2012)Objective: To assess the effects of high-fat feeding on white adipose tissue gene expression and liver oxidative stress.Research Methods and Procedures: Male Wistar rats were fed on standard pelleted or high-fat diet to ... -
Pro12Ala variant of the PPARG2 gene increases body mass index: An updated meta-analysis encompassing 49,092 subjects
(John Wiley & Sons, Ltd, 2013)Objective The peroxisome proliferator-activated receptor gamma 2 (PPARG2) gene has been intensively studied with relation to obesity and metabolic disorders. Indeed, a large number of studies assessing the association ... -
Source and regulation of flux variability in Escherichia coli
(Springer Nature Link, 2014)Background: Metabolic responses are essential for the adaptation of microorganisms to changing environmental conditions. The repertoire of flux responses that the metabolic network can display in different external ... -
Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: The PREDIMED-NAVARRA trial
(Springer Nature Link, 2014)The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet–gene interactions have been poorly evaluated. We aimed to investigate diet–gene interaction in the ... -
Mediterranean diet and cognitive function: The sun project
(Elsevier, 2015)Objective Our aim was to evaluate the association between adherence to the Mediterranean Diet (MedDiet) and cognitive function in 823 participants (62 ± 6 years at baseline) from a Spanish prospective cohort (SUN ... -
Clinical efficacy and immunological changes subjacent to egg oral immunotherapy
(Elsevier, 2015)Background Evidence of the efficacy of food oral immunotherapy (OIT) is not robust enough to change clinical practice from current standard management. Furthermore, the immunologic changes underlying food desensitization ...
