Zerrendatu honen arabera: egilea "6fceebe2b320bcfbeae89218dcc092e1"
-
11-β Hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity
Milagro, Fermin I.; Campion, Javier; Martínez, José A. (Elsevier, 2007)Glucocorticoid action within the cells is regulated by the levels of glucocorticoid receptor (GR) expression and two enzymes, 11-β hydroxysteroid dehydrogenase type 1 (11βHSD1), which converts inactive to active glucocorticoids, ... -
Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers
Garcia-Diaz, Diego; Campion, Javier; Milagro, Fermin I.; Martínez, José A. (Springer Nature Link, 2007)It has been reported that apelin functions as an adipokine, which has been associated to obesity and insulin resistance. The objective of this study was to analyze the apelin mRNA expression in white adipose tissue ... -
Aldosterone impairs insulin responsiveness in U-937 human promonocytic cells via the downregulation of its own receptor
Campion, Javier; Maestro, Begoña; Molero, S.; dávila, norma; Carranza, María del Carmen; Calle, Consuelo (John Wiley & Sons, Ltd, 2002)n an earlier study, we have reported an inhibition of insulin receptor (IR) mRNA levels and insulin binding by aldosterone in U-937 human promonocytic cells. In the present extension of our studies, we demonstrate that ... -
Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1 Available to Purchase
SUBRAMANIAM, Nanthakumar; Campion, Javier; RAFTER, Ingalill; OKRET, Sam (Biochemical society, 2003)Glucocorticoid (GC) signalling influences the response of the cell to a number of other signals via a mechanism referred to as ‘cross-talk'. This cross-talk may act at several levels, including an interaction between the ... -
Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity
Campion, Javier; Milagro, Fermin I.; Fernández, D.; Martínez, J.A, (Springer Nature Link, 2006)Obesity is considered as an inflammatory disease, in which free radical-induced oxidative stress and excessive intake of macronutrients exacerbate their symptoms. In this context, we assessed in rats the possible preventive ... -
Epinephrine-Induced Reduction in Insulin Receptor mRNA Level and Stability in U-937 Human Promonocytic Cells
Mas, Antonio; Campion, Javier; Aller, Patricio; calle, consuelo (Thieme E-Journals, 1998)The administration of 10-5 M epinephrine transiently decreased insulin receptor (IR) mRNA levels in U-937 human promonocytic cells, which reached their minimum value after 24 hours. Such a decrease seems to be due, at least ... -
In vivo tissue specific modulation of rat insulin receptor gene expression in an experimental model of mineralocorticoid excess
Campion, Javier; Lahera, Vicente; Cachofeiro, Victoria; Maestro, Begoña; dávila, norma; Carranza, María del Carmen; calle, consuelo (Springer Nature Link, 1998)Insulin receptor (IR) gene expression at the mRNA level was investigated in hindlimb skeletal muscle, epididymal adipose tissue and in the liver of rats exposed to prolonged in vivo administration of deoxycorticosterone ... -
Inhibition by aldosterone of insulin receptor mRNA levels and insulin binding in U-937 human promonocytic cells
Campion, Javier; Maestro, Begoña; Mata, Felicísima; dávila, norma; Carranza, María del Carmen; calle, consuelo (Elsevier, 1999)The effect of aldosterone on insulin receptor (IR) expression was investigated in U-937 human promonocytic cells. The putative involvement of the mineralocorticoid receptor (MR) was also analysed. Aldosterone binding assays ... -
Ketoconazole, an Antifungal Agent, Protects Against Adiposity Induced by a Cafeteria Diet
Campion, Javier; Martinez, Alfredo (2004)Ketoconazole, an anti-glucocorticoid agent, is widely used in humans as an antifungal agent. It inhibits ergosterol synthesis and reduces cortisol levels in the treatment of Cushing’s Syndrome. The aim of this work was to ... -
Tissue-specific modulation of insulin receptor mRNA levels in adrenaline-treated rats
Campion, Javier; Aller, Patricio; dávila, norma; Carranza, María del Carmen; de miguel, rosario; calle, consuelo (Springer Nature Link, 1997-04)Insulin receptor (IR) gene expression at the mRNA level was investigated in liver, hindlimb skeletal muscle, and epididymal adipose tissue of rats exposed to prolonged in vivo administration of adrenaline in relation to ... -
Vitamin C Supplementation Influences Body Fat Mass and Steroidogenesis-Related Genes when Fed a High-Fat Diet
Campion, Javier; Milagro, Fermin I.; Fernandez Orth, Dietmar; Martínez, J. Alfredo (Hogrefe AG, 2008)An enhanced oxidative stress status has been documented in obese patients and animal models, and a depletion of the antioxidant mechanisms in these conditions is a common feature. Therefore, we have tested the hypothesis ... -
Weight gain induced by high-fat feeding involves increased liver oxidative stress
Milagro, Fermin I.; Campion, Javier; Martínez, José A. (John Wiley & Sons, Ltd, 2012)Objective: To assess the effects of high-fat feeding on white adipose tissue gene expression and liver oxidative stress.Research Methods and Procedures: Male Wistar rats were fed on standard pelleted or high-fat diet to ...
