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dc.rights.licenseAttribution 4.0 International*
dc.contributor.authorRomero-Bascones, David
dc.contributor.authorAyala, Unai
dc.contributor.authorBarrenechea, Maitane
dc.contributor.otherMurueta Goyena, Ane
dc.contributor.otherTeijeira Portas, Sara
dc.contributor.otherUrcola, J. Aritz
dc.contributor.otherRuiz Martínez, Javier
dc.contributor.otherdel Pino, Rocío
dc.contributor.otherAcera, Marian
dc.contributor.otherPetzold, Axel
dc.contributor.otherWagner, Siegfried Karl
dc.contributor.otherKeane, Pearse Andrew
dc.contributor.otherTijero, Beatriz
dc.contributor.otherGómez Esteban, Juan Carlos
dc.contributor.otherGabilondo, Iñigo
dc.date.accessioned2024-04-08T14:42:05Z
dc.date.available2024-04-08T14:42:05Z
dc.date.issued2024
dc.identifier.issn2373-8057en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=174372en
dc.identifier.urihttps://hdl.handle.net/20.500.11984/6328
dc.description.abstractRetinal thickness may serve as a biomarker in Parkinson’s disease (PD). In this prospective longitudinal study, we aimed to determine if PD patients present accelerated thinning rate in the parafoveal ganglion cell-inner plexiform layer (pfGCIPL) and peripapillary retinal nerve fiber layer (pRNFL) compared to controls. Additionally, we evaluated the relationship between retinal neurodegeneration and clinical progression in PD. A cohort of 156 PD patients and 72 controls underwent retinal optical coherence tomography, visual, and cognitive assessments between February 2015 and December 2021 in two Spanish tertiary hospitals. The pfGCIPL thinning rate was twice as high in PD (β [SE] = −0.58 [0.06]) than in controls (β [SE] = −0.29 [0.06], p < 0.001). In PD, the progression pattern of pfGCIPL atrophy depended on baseline thickness, with slower thinning rates observed in PD patients with pfGCIPL below 89.8 µm. This result was validated with an external dataset from Moorfields Eye Hospital NHS Foundation Trust (AlzEye study). Slow pfGCIPL progressors, characterized by older at baseline, longer disease duration, and worse cognitive and disease stage scores, showed a threefold increase in the rate of cognitive decline (β [SE] = −0.45 [0.19] points/year, p = 0.021) compared to faster progressors. Furthermore, temporal sector pRNFL thinning was accelerated in PD (βtime x group [SE] = −0.67 [0.26] μm/year, p = 0.009), demonstrating a close association with cognitive score changes (β [SE] = 0.11 [0.05], p = 0.052). This study suggests that a slower pattern of pfGCIPL tissue loss in PD is linked to more rapid cognitive decline, whereas changes in temporal pRNFL could track cognitive deterioration.es
dc.language.isoengen
dc.publisherSpringer Natureen
dc.rights© 2024 The Authorsen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAssociation of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s diseaseen
dcterms.accessRightshttp://purl.org/coar/access_right/c_abf2en
dcterms.sourcenpj Parkinson's Diseaseen
local.contributor.groupTeoría de la señal y comunicacioneses
local.description.peerreviewedtrueen
local.identifier.doihttps://doi.org/10.1038/s41531-024-00637-xen
local.contributor.otherinstitutionhttps://ror.org/04fkwzm96en
local.contributor.otherinstitutionhttps://ror.org/01zc1f144en
local.contributor.otherinstitutionhttps://ror.org/03nzegx43en
local.contributor.otherinstitutionhttps://ror.org/01cc3fy72en
local.contributor.otherinstitutionhttps://ror.org/004hydx84en
local.contributor.otherinstitutionhttps://ror.org/000xsnr85en
local.contributor.otherinstitutionhttps://ror.org/02jx3x895en
local.contributor.otherinstitutionInstituto de Investigación Sanitaria Biobizkaia
local.contributor.otherinstitutionInstituto de Investigación Sanitaria Biobizkaia
local.contributor.otherinstitutionCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)
local.contributor.otherinstitutionhttps://ror.org/05grdyy37
local.source.detailsVol. 10. N. art. 26
oaire.format.mimetypeapplication/pdfen
oaire.file$DSPACE\assetstoreen
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501en
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85en


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