Browsing by Author "1acf7861d7aa1d60009dfc9d257a6ac3"
Now showing items 1-13 of 13
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Advancing retinal OCT image analysis as a biomarker for Parkinson’s disease
Romero-Bascones, David (Mondragon Unibertsitatea. Goi Eskola Politeknikoa, 2023)The number of people worldwide affected by Parkinson’s disease (PD) is increasing every year. This is a worrying trend, which requires new biomarkers to better diagnose and monitor the disease. Research to date has ... -
Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease
Romero-Bascones, David; Ayala, Unai; Barrenechea, Maitane (Springer Nature, 2024)Retinal thickness may serve as a biomarker in Parkinson’s disease (PD). In this prospective longitudinal study, we aimed to determine if PD patients present accelerated thinning rate in the parafoveal ganglion cell-inner ... -
Caracterización de la morfología foveal: parametrización, diferencias de sexo y efectos de la edad
Romero-Bascones, David; Gabilondo, Iñigo; Barrenechea, Maitane; Ayala, Unai (Congreso Anual de la Sociedad Española de Ingeniería Biomédica CASEIB, 2020)Frente a los análisis convencionales de grosores de la retina, el análisis morfológico de la fóvea presenta una metodología alternativa de gran potencial pero poco explorada. En este estudio se implementa un pipeline ... -
Clinical long-term nocturnal sleeping disturbances and excessive daytime sleepiness in Parkinson's disease
Ayala, Unai (PLOS, 2021)Objective To prospectively evaluate nocturnal sleep problems and excessive daytime sleepiness (EDS) in Parkinson’s disease (PD) patients, and analyze the influence of motor symptoms, treatment, and sex differences on sleep ... -
Correlatos estructurales, microvasculares y electrofisiológicos retinianos de los biomarcadores plasmáticos en enfermedad de Alzheimer
Teijeira Portas, Sara; Murueta Goyena, Ane; Zamora, Aitor; Perez, Raquel; Fernández, Manuel; Almeida, Javier; Blanco, Elisa; Sainz Lugarezaresti, Unai; Gonzalez, Tirso; Ayala, Unai; Barrenechea, Maitane; Zuazo Atutxa, Garazi; Acera, Marian; del Pino, Rocío; Gabilondo, Iñigo (2025)Objetivo: Investigar la asociación entre biomarcadores plasmáticos de la enfermedad de Alzheimer (EA) y parámetros estructurales, vasculares y funcionales de la retina —medidos mediante OCT, OCT-A y ERG— en sujetos con EA ... -
Deep Learning-based age prediction models from retinal Optical Coherence Tomography images
Zuazo Atutxa, Garazi; Ayala, Unai; Gabilondo, Iñigo; Barrenechea, Maitane (Sociedad Española de Ingeniería Biomédica, 2025)This study evaluates the potential of Optical Coherence Tomog raphy (OCT) as a non-invasive tool for retinal age prediction in healthy individuals. A dataset comprising 1,180 eyes from 517 con trol subjects was used to ... -
Evaluación del potencial de las imágenes OCT maculares para el diagnóstico de la enfermedad de Parkinson
Romero-Bascones, David; Barrenechea, Maitane; Ayala, Unai (Universidad de Valladolid, 2022) -
Foveal Pit Morphology Characterization: A Quantitative Analysis of the Key Methodological Steps
Romero-Bascones, David; Barrenechea, Maitane; Ayala, Unai (MDPI, 2021)Disentangling the cellular anatomy that gives rise to human visual perception is one of the main challenges of ophthalmology. Of particular interest is the foveal pit, a concave depression located at the center of the ... -
Foveal Remodeling of Retinal Microvasculature in Parkinson’s Disease
Barrenechea, Maitane; Erramuzpe Aliaga, Asier; Ayala, Unai; Romero-Bascones, David (Frontiers, 2021)Background: Retinal microvascular alterations have been previously described in Parkinson’s disease (PD) patients using optical coherence tomography angiography (OCT-A). However, an extensive description of retinal vascular ... -
Heart-brain synchronization breakdown in Parkinson’s disease
Erramuzpe Aliaga, Asier (Springer Nature, 2022)Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization ... -
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
Romero-Bascones, David; Ayala, Unai (Springer Nature, 2023)Background Cognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal layer thickness seems to be a good biomarker of cognition in other ... -
Retinal thickness predicts the risk of cognitive decline in Parkinson's disease
Ayala, Unai; Barrenechea, Maitane (Wiley, 2021)Objective: To analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson’s disease (iPD). Methods: Patients with Lewy body diseases (LBDs) ... -
Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
Romero-Bascones, David; Ayala, Unai; Alberdi Aramendi, Ane; Erramuzpe Aliaga, Asier; Barrenechea, Maitane (PLoS, 2022)Characterizing the effect of age and sex on macular retinal layer thicknesses and foveal pit morphology is crucial to differentiating between natural and disease-related changes. We applied advanced image analysis techniques ...
