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dc.rights.licenseAttribution-NonCommercial 4.0 International*
dc.contributor.authorTorca de la Concepción, Ireneo
dc.contributor.authorEsnaola Ramos, Jon Ander
dc.contributor.otherAzinas, Stavros
dc.contributor.otherRichter, Ralf P.
dc.contributor.otherAbrescia, Nicola G.
dc.contributor.otherBano, Fouzia
dc.contributor.otherBamford, Dennis Henry
dc.contributor.otherSchwart, Gustavo A.
dc.contributor.otherOksanen, Hanna Maarit
dc.date.accessioned2020-06-16T09:02:52Z
dc.date.available2020-06-16T09:02:52Z
dc.date.issued2018
dc.identifier.issn2040-3372en
dc.identifier.otherhttps://katalogoa.mondragon.edu/janium-bin/janium_login_opac.pl?find&ficha_no=145617en
dc.identifier.urihttp://hdl.handle.net/20.500.11984/1691
dc.description.abstractThe protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport.en
dc.description.sponsorshipGobierno de Españaes
dc.description.sponsorshipGobierno de Españaes
dc.description.sponsorshipUnión Europeaes
dc.language.isoengen
dc.publisherRoyal Society of Chemistryen
dc.rights© The Royal Society of Chemistry 2018en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleMembrane-containing virus particles exhibits mechanics of a composite material for genome protectionen
dc.typeinfo:eu-repo/semantics/articleen
dcterms.accessRightsinfo:eu-repo/semantics/openAccessen
dcterms.sourceNanoscaleen
dc.description.versioninfo:eu-repo/semantics/publishedVersionen
local.contributor.groupDiseño y mecánica estructurales
local.description.peerreviewedtrueen
local.description.publicationfirstpage7769en
local.description.publicationlastpage7779en
local.identifier.doihttp://dx.doi.org/10.1039/c8nr00196ken
local.relation.projectIDGE/Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad, Convocatoria 2015/BFU2015-64541-R/ES/Descifrando los procesos del ciclo vital del virus con membrana mediante técnicas estructurales/en
local.relation.projectIDSevero Ochoa Excellence Accreditation to the CIC bioGUNE SEV-2016-0644en
local.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/306435/EU/Biomolecular Hydrogels from Supramolecular Organization and Dynamics to Biological Function/JELLYen
local.rights.publicationfeeAPCen
local.rights.publicationfeeamount1182 EURen
local.contributor.otherinstitutionCIC Biogunees
local.contributor.otherinstitutionCIC biomaGUNEes
local.contributor.otherinstitutionUniversity of Helsinkies
local.contributor.otherinstitutionUniversity of Leedses
local.contributor.otherinstitutionIkerbasquees
local.source.detailsVol. 10. Nº 16. Pp. 7769–7779. Nanoscale. Published online April 16, 2018eu_ES


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International